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Description
Every B2B company regardless of industry, growth stage, or offering experiences the same seven GTM breakdowns. These failures don’t always show up in dashboards or board decks, but they reveal themselves in missed revenue, margin erosion, bloated CAC, churn, and stalled execution.
This session explores the universal patterns that quietly undermine performance, including one of the most overlooked drivers: misalignment between product and revenue teams. From disconnected product roadmaps to under-leveraged enablement and fragmented customer handoffs, these breakdowns are predictable and fixable.
We’ll go beyond diagnosing the problems to show what elite leaders including product and revenue executives are doing to fix them. Using structure, shared operating rhythms, and full lifecycle accountability, they are turning cross-functional friction into revenue momentum.
Whether you're building, scaling, or optimizing, this session offers a framework to identify, prioritize, and seal the costliest cracks in your revenue machine across Sales, Marketing, Product, and Customer Success.
By the end of this session, participants will be able to:
- Identify the seven universal breakdown patterns that occur across all B2B companies, regardless of industry or growth stage.
- Understand the strategic role of Product in alignment, including how disconnected product roadmaps and feedback loops contribute to stalled growth.
- Leave with a tangible Diagnostic Tool and Leadership Playbook to immediately assess breakdowns across your org and apply corrective action in Sales, Product, Marketing, and CS.
About the Speaker

Karen Loiterstein, MBA, VP, Revenue Enablement
Karen Loiterstein is a strategic revenue architect who transforms Sales, Marketing, and Customer Success teams into high-performing, revenue-generating engines. With a track record of building and scaling eight commercial teams, she helps organizations break through barriers and position themselves for sustained growth. Known for her ability to bring structure to complexity, Karen excels at aligning revenue functions in a way that is both practical and high-impact. Her approach is data-driven, execution-focused, and designed to turn strategy into measurable results.
Karen has pioneered first-of-its-kind initiatives at nationally recognized companies, including Equifax, MCI WorldCom, Enterprise Bank & Trust, and Willis Towers Watson, where she played a key role in aligning revenue functions and driving measurable growth. A sought-after speaker at global conferences, she shares insights on data-driven marketing, revenue enablement, and sales & marketing alignment, helping organizations modernize and scale their revenue functions for long-term success.
Her ability to build high-performing teams and drive strategic transformation began early in her career. At FleishmanHillard, she quickly rose to lead marketing for the Change Communications function. She later joined Express Scripts, where she designed and launched the company’s first enterprise-wide prospecting strategy and Sales Enablement function, directly contributing to a $6M YOY gross margin increase.
Currently serving as Vice President, Revenue Enablement at TierPoint, Karen has played a pivotal role in driving sales productivity, customer retention, and revenue acceleration. Under her leadership, TierPoint achieved 102% of bookings attainment in 2024, reduced new hire ramp time by 50%, and increased quota attainment by 25%. She has been promoted twice and established TierPoint’s first-ever Revenue Enablement and Customer Success teams, ensuring a seamless, customer-centric approach to revenue growth.
Karen's expertise has been recognized with the Program of the Year Award from SiriusDecisions (now Forrester) for her outstanding work in building sales operations for a $20B asset bank. She is deeply committed to community leadership, serving on the Executive Committee for Boys Hope Girls Hope, Executive Connections St. Louis, and as a former International President of BBYO. She frequently presents on the topics of GTM effectiveness, sales and marketing alignment and modernizing revenue engines.
Karen holds an MBA from the University of Missouri–St. Louis and graduated with honors in English and Communication Studies from the University of Kansas. She resides in St. Louis with her husband and three children.